| 学位：博士 |
研究中心：畜产品加工与质量安全控制中心 | |
研究领域：益生菌资源与功能挖掘；肠道微生态与营养 | |
邮箱：zhifengf@foxmail.com | |
办公电话： | |
通讯地址：新疆威尼斯wnsr888(中国)股份有限公司 | |
职位： |
个人简介
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方志锋，博士研究生学历，博士后，中共党员，威尼斯wnsr888(中国)股份有限公司讲师。主要研究方向为益生菌资源与功能挖掘，肠道微生态与精准营养。主持及完成省部级科研项目3项，近5年发表专业学术论文32篇。申请发明专利15项，其中国际专利3项，授权8项，参与中英文专著编写2项，参与教材编写2项。
社会兼职
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iMeta青年编委，Microbiome，BMC Genomics审稿人，Review Editor for Microbial Immunology（Frontiers in Immunology/Microbiology/Nutrition/ Pharmacology）；Frontiers in Allergy Topic Editor
科研学术工作经历与教育背景
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2022.9--至今 新疆威尼斯wnsr888(中国)股份有限公司，讲师
2020.8--2022.8 江南大学威尼斯wnsr888，博士后，助理研究员
2015.8--2020.8 江南大学威尼斯wnsr888，博士
2014.7--2015.7 河南兴泰实业科技有限公司研发中心
2011.9--2014.6 河南工业大学食品科学与工程，硕士
2007.9--2011.6 许昌学院食品科学与工程专业，本科
研究方向：
1．功能益生菌的资源挖掘和整理。
2．肠道微生态与营养健康。
科研项目
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1. 2021--2022 主持江苏省博士后A等科研资助计划（结题）
2. 2022--2025 主持江苏省基础研究计划(自然科学基金)青年基金（在研）
3. 2020--2023 国家自然科学基金-基于糖苷水解酶研究中国人群肠道中长双歧杆菌分子适应性机制（参加）
学术论文
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1. Fang, Z., L. Li, X. Liu, W. Lu, J. Zhao, H. Zhang, W. Chen, Strain-specific ameliorating effect of Bifidobacterium longum on atopic dermatitis in mice. J Funct Foods, 2019, 60, 103426.
2. Fang, Z., L. Li, W. Lu, J. Zhao, H. Zhang, Y. Lee, W. Chen, Bifidobacterium affected the correlation between gut microbial composition, SCFA metabolism, and immunity in mice with DNFB-induced atopic dermatitis. Food Bioscience, 2021, 41, 100648.
3. Fang, Z., T. Pan, H. Wang, J. Zhu, H. Zhang, J. Zhao, W. Chen, and W. Lu, Limosilactobacillus reuteri Attenuates Atopic Dermatitis via Changes in Gut Bacteria and Indole Derivatives from Tryptophan Metabolism. Int J Mol Sci, 2022. 23(14).
4. Fang, Z., T. Pan, L. Li, H. Wang, J. Zhu, H. Zhang, J. Zhao, W. Chen, and W. Lu, Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis. Gut Microbes, 2022. 14(1): p. 2044723.
5. Fang, Z., W. Lu, J. Zhao, H. Zhang, L. Qian, Q. Wang, and W. Chen, Probiotics modulate the gut microbiota composition and immune responses in patients with atopic dermatitis: a pilot study. Eur J Nutr, 2020. 59(5): p. 2119-2130.
6. Fang, Z., L. Li, J. Zhao, H. Zhang, Y.K. Lee, W. Lu, and W. Chen, Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice. Eur J Nutr, 2020. 59(7): p. 3069-3081.
7. Fang, Z., L. Li, H. Zhang, J. Zhao, W. Lu, and W. Chen, Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review. Front Immunol, 2021. 12: p. 720393.
8. Wang, X., S. Lu, Z. Fang, H. Wang, J. Zhu, J. Zhao, H. Zhang, K. Hong, W. Lu, and W. Chen, A recommended amount of hydrolyzed protein improves physiological function by regulating gut microbiota in aged mice. Food Res Int, 2022. 154: p. 110970.
9. Lu, W., Y. Wang, Z. Fang, H. Wang, J. Zhu, Q. Zhai, J. Zhao, H. Zhang, and W. Chen, Bifidobacterium longum CCFM752 prevented hypertension and aortic lesion, improved antioxidative ability, and regulated the gut microbiome in spontaneously hypertensive rats. Food Funct, 2022. 13(11): p. 6373-6386.
10. Lu, W., L. Qian, Z. Fang, H. Wang, J. Zhu, Y.K. Lee, J. Zhao, H. Zhang, and W. Chen, Probiotic strains alleviated OVA-induced food allergy in mice by regulating the gut microbiota and improving the level of indoleacrylic acid in fecal samples. Food Funct, 2022. 13(6): p. 3704-3719.
11. Liu, Z., H. Li, L. Li, Q. Ma, Z. Fang, H. Wang, Y. Lee, J. Zhao, H. Zhang, W. Chen, et al., Gene-trait matching analysis reveals putative genes involved in Bifidobacterium spp. biofilm formation. Gene, 2022. 826: p. 146449.
12. Li, L., Z. Fang, Y.K. Lee, J. Zhao, H. Zhang, H. Peng, Y. Zhang, W. Lu, and W. Chen, Efficacy and Safety of Lactobacillus reuteri CCFM1040 in Allergic Rhinitis and Asthma: A Randomized, Placebo-Controlled Trial. Front Nutr, 2022. 9: p. 862934.
13. Jiang, T., W. Lu, Z. Fang, H. Wang, J. Zhu, H. Zhang, and J. Zhao, Bifidobacterium Treated by Electrostatic Spray Drying Relieved Constipation by Changing the Relative Abundance of Bacteria Associated With Gastrointestinal Regulatory Peptides. Front Cell Infect Microbiol, 2022. 12: p. 894216.
14. Hu, W., W. Gao, Z. Liu, Z. Fang, J. Zhao, H. Zhang, W. Lu, and W. Chen, Biodiversity and Physiological Characteristics of Novel Faecalibacterium prausnitzii Strains Isolated from Human Feces. Microorganisms, 2022. 10(2).
15. Hu, W., W. Gao, Z. Liu, Z. Fang, H. Wang, J. Zhao, H. Zhang, W. Lu, and W. Chen, Specific Strains of Faecalibacterium prausnitzii Ameliorate Nonalcoholic Fatty Liver Disease in Mice in Association with Gut Microbiota Regulation. Nutrients, 2022. 14(14).
16. Wang, Y., Z. Fang, Q. Zhai, S. Cui, J. Zhao, H. Zhang, W. Chen, and W. Lu, Supernatants of Bifidobacterium longum and Lactobacillus plantarum Strains Exhibited Antioxidative Effects on A7R5 Cells. Microorganisms, 2021. 9(2).
17. Ma, S., C. Qian, N. Li, Z. Fang, J. Zhao, H. Zhang, W. Chen, Z. Liu, and W. Lu, Protein diets with the role of immune and gut microbial regulation alleviate DSS-induced chronic ulcerative colitis. Food Sci Nutr, 2021. 9(3): p. 1259-1270.
18. Ma, Q., Z. Pei, Z. Fang, H. Wang, J. Zhu, Y.K. Lee, H. Zhang, J. Zhao, W. Lu, and W. Chen, Evaluation of Tetracycline Resistance and Determination of the Tentative Microbiological Cutoff Values in Lactic Acid Bacterial Species. Microorganisms, 2021. 9(10).
19. Lu, W., Z. Fang, X. Liu, L. Li, P. Zhang, J. Zhao, H. Zhang, and W. Chen, The Potential Role of Probiotics in Protection against Influenza a Virus Infection in Mice. Foods, 2021. 10(4).
20. Lu, W., Y. Deng, Z. Fang, Q. Zhai, S. Cui, J. Zhao, W. Chen, and H. Zhang, Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice. Nutrients, 2021. 13(6).
21. Liu, Z., L. Li, Z. Fang, Y. Lee, J. Zhao, H. Zhang, W. Chen, H. Li, and W. Lu, Integration of Transcriptome and Metabolome Reveals the Genes and Metabolites Involved in Bifidobacterium bifidum Biofilm Formation. Int J Mol Sci, 2021. 22(14).
22. Liu, S., Z. Fang, H. Wang, Q. Zhai, F. Hang, J. Zhao, H. Zhang, W. Lu, and W. Chen, Gene-Phenotype Associations Involving Human-Residential Bifidobacteria (HRB) Reveal Significant Species- and Strain-Specificity in Carbohydrate Catabolism. Microorganisms, 2021. 9(5).
23. Jin, Z., Z. Fang, Z. Pei, H. Wang, J. Zhu, Y.K. Lee, H. Zhang, J. Zhao, W. Lu, and W. Chen, A low molecular weight brown algae Laminaria japonica glycan modulation of gut microbiota and body weight in mice. Food Funct, 2021. 12(24): p. 12606-12620.
24. Gao, F., Z. Fang, and W. Lu, Regulation divergences of Lactobacillus fermentum PCC and Lactobacillus paracasei 431 on penicillin-induced upper respiratory tract microbial dysbiosis in BALB/c mice. Food Funct, 2021. 12(23): p. 11913-11925.
25. Li, L., Z. Fang, X. Liu, W. Hu, W. Lu, Y.K. Lee, J. Zhao, H. Zhang, and W. Chen, Lactobacillus reuteri attenuated allergic inflammation induced by HDM in the mouse and modulated gut microbes. PLoS One, 2020. 15(4): p. e0231865.
26. Li, L., Z. Fang, Y.K. Lee, J. Zhao, H. Zhang, W. Lu, and W. Chen, Prophylactic effects of oral administration of Lactobacillus casei on house dust mite-induced asthma in mice. Food Funct, 2020. 11(10): p. 9272-9284.
27. X. Liu, Z. Fang, Y. Deng, W. Lu, P. Zhang, J. Zhao, H. Zhang, W. Chen, Oral administration of probiotics protected mice from influenza virus infection. Food Bioscience, 2021, 41, 100804.
28. L. Li; Z. Fang, Z. Liu, J. Zhao, H. Zhang, S. Wang, J. He, W. Lu, W. Chen, Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice. J Funct Foods, 2021, 76, 104286.
29. Y. Deng, Z. Fang, S. Cui, J. Zhao, H. Zhang, W.Chen, W. Lu, Evaluation of probiotics for inhibiting hyperproliferation and inflammation relevant to psoriasis in vitro. J Funct Foods, 2021, 81, 104433.
30. Q. Wang, Z. Fang, L. Li, H. Wang, J. Zhu, P. Zhang, Y. Lee, J. Zhao, H. Zhang, W. Lu, W. Chen, Lactobacillus mucosae exerted different antiviral effects on respiratory syncytial virus infection in mice. Front Microbiol, 2022, doi: 10.3389/fmicb.2022.1001313.
31.王心怡, 陆守荣, ……方志锋 (通讯作者),不同来源蛋白对小鼠衰老和肠道菌群的影响，食品与发酵工业，2022, 10.13995/j.cnki.11-1802/ts.029514;
32.方志锋, 赵国忠, 李海涛等, 益生菌对高血压影响的研究进展, 食品科学, 2018, 39(15): 254-261.;
获奖
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专利
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1. 2014.10 一种高效降解木质纤维素原料的方法 ZL201310187931.2
2. 2015.5 一种复合改性大豆蛋白塑料及其制备方法 ZL201310486292.X
3. 2015.7 一种多重改性大豆蛋白生物降解塑料及其制备方法 ZL201310202594.X
4. 2016.4 一种萃取大豆蛋白并提纯和回收表面活性剂的方法 ZL201310486292.X
5. 2016.5 一种糖基化与酶解改性复合制备低敏性大豆蛋白粉的方法 ZL201410195415.9
6. 2017.1 一种胶原蛋白与小麦蛋白复合可食性肠衣膜及其制备方法 ZL201410351154.5
7. 2021.3 一株能够缓解特应性皮炎的长双歧杆菌及其应用 ZL201910777578.0
8. 2022.2 能够缓解特应性皮炎的双歧杆菌及其应用 ZL201910777578.0
9. 2018.11 一种能够缓解特应性皮炎的植物乳杆菌CCFM8610的应用 201811404822.0（实质审查）
10. 2021.5 Bifidobacterium Longum with the Ability to Relieve Atopic Dermatitis and its Application, 17/325,280（USA）
11. 2021.9 Bifidobacterium longum capable of relieving atopic dermatitis and use thereof 2019431515（Australia）
12. 2021.9 BIFIDOBACTERIUM LONGUM CAPABLE OF RELIEVING ATOPIC DERMATITIS AND USE THEREOF, 19916863.4（European）
13. 2021.10 一株能够提高吲哚丙烯酸以调节特异性IgE的罗伊氏乳杆菌 202111204012.2（实质审查）
14. 2021.10 一株调节OVA特异性IgE的植物乳杆菌及其应用 202111203923.3（实质审查）
15. 2021.12 一种长双歧杆菌婴儿亚种CCFM1192菌株、发酵剂及其制备方法与应用 202111654017.5（实质审查）
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